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苏丹恶性疟原虫分离株中的高水平氯喹抗性与氯喹抗性转运蛋白基因pfcrt和多药抗性基因pfmdr1的突变有关。

High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1.

作者信息

Babiker H A, Pringle S J, Abdel-Muhsin A, Mackinnon M, Hunt P, Walliker D

机构信息

Institute of Cell, Animal, and Population Biology, University of Edinburgh, Edinburgh, EH9 3JT, Scotland, United Kingdom.

出版信息

J Infect Dis. 2001 May 15;183(10):1535-8. doi: 10.1086/320195. Epub 2001 Apr 13.

DOI:10.1086/320195
PMID:11319692
Abstract

Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance gene pfmdr1-Y86 allele. A significant association between pfmdr1-Y86 and pfcrt-T76 was apparent among resistant isolates, which suggests a joint action of the 2 genes in high-level chloroquine resistance.

摘要

对2个恶性疟原虫基因中的多态性进行了检测，同时还检测了来自苏丹东部一个村庄的克隆和分离株对氯喹的反应。恶性疟原虫氯喹抗性转运蛋白基因（pfcrt-T76）的一个等位基因与体外和体内抗性之间存在显著关联。与多药抗性基因pfmdr1-Y86等位基因的关联不太显著。在抗性分离株中，pfmdr1-Y86与pfcrt-T76之间存在显著关联，这表明这两个基因在高水平氯喹抗性中共同起作用。

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High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1.苏丹恶性疟原虫分离株中的高水平氯喹抗性与氯喹抗性转运蛋白基因pfcrt和多药抗性基因pfmdr1的突变有关。
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