National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China.
National Center for International Research on Tropical Diseases, Shanghai, China.
Front Cell Infect Microbiol. 2023 May 9;13:1167220. doi: 10.3389/fcimb.2023.1167220. eCollection 2023.
China has now achieved the elimination of malaria, but it still faces severe challenges in the post-elimination stage. China continues to be plagued by imported malaria cases, and preventing re-transmission of imported malaria is critical. The effectiveness of antimalarial drugs for malaria control largely depends on the study of drug resistance markers . Monitoring molecular markers of parasite-associated drug resistance can help predict and manage drug resistance. There is currently a lack of systematic reviews of molecular markers for indigenous and imported malaria in China. Therefore, this review summarizes the published articles related to molecular marker polymorphism of indigenous and imported malaria cases in China in the past two decades, to study the mutation frequency and distribution of , , , and gene resistance-related loci. This can provide a whole picture of molecular markers and the resistance mutations of imported cases in China, which has certain significance for drug resistance surveillance planning, safe and effective treatment, and preventing the recurrence of local transmission by imported malaria in China in the future.
中国现已消除疟疾，但在消除后的阶段仍面临严峻挑战。中国仍受到输入性疟疾病例的困扰，防止输入性疟疾再传播至关重要。抗疟药物控制疟疾的效果在很大程度上取决于对耐药性标志物的研究。监测寄生虫相关药物耐药性的分子标志物有助于预测和管理耐药性。目前，中国尚未对本土和输入性疟疾的分子标志物进行系统评价。因此，本综述总结了过去 20 年中国本土和输入性疟疾病例的分子标记物相关研究，以研究 、 、 、 和 基因耐药相关位点的突变频率和分布。这可以为中国输入性疟疾病例的分子标志物和耐药突变提供全貌，对未来中国抗疟药物耐药性监测规划、安全有效治疗以及防止输入性疟疾导致的本地传播复发具有一定意义。
