Rumpl E, Hackl J M, Gerstenbrand F, Bauer G
EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1979 Jun;10(2):88-94.
EEG studies were done in 19 patients comatose due to severe hepatic insufficiency associated with porto-caval shunting. The neurological deficits were graded in 5 stages and related to the abnormal EEG-pattern observed in 38 records. With deepening of coma, alpha-frequencies were gradually replaced by theta- and delta-activities. The frequency of theta- and delta-runs decreased with neurological deterioration. Triphasic waves (typical and/or atypical) were seen in 26% of the records. Typical triphasic waves were found to be limited to stage 3 of coma, whereas atypical forms appeared in earlier and later stages. After infusions of L-Valin, a transient improvement and disappearance of triphasic waves was observed, but no significant effect could be established on the final course of the disease. Sleep-like potentials and the reactivity to external stimuli decreased in deep stages of coma. Severe EEG abnormalities were correlated to low cholinesterase and high lactid acid blood level, but no correlation was found to the level of ammonia.
对19例因严重肝功能不全伴门腔分流而昏迷的患者进行了脑电图研究。神经功能缺损分为5个阶段，并与38份记录中观察到的异常脑电图模式相关。随着昏迷程度加深，α波频率逐渐被θ波和δ波活动取代。θ波和δ波阵发的频率随着神经功能恶化而降低。在26%的记录中可见三相波（典型和/或非典型）。典型三相波仅限于昏迷第3阶段，而非典型形式出现在较早和较晚阶段。输注L-缬氨酸后，观察到三相波短暂改善并消失，但对疾病的最终病程未发现显著影响。在昏迷的深度阶段，睡眠样电位和对外界刺激的反应性降低。严重的脑电图异常与低胆碱酯酶和高乳酸血症相关，但与氨水平无关。
