Ratrema M, Guy C, Nelva A, Benedetti C, Beyens M N, Grasset L, Ollagnier M
Centre Régional de Pharmacovigilance et de Renseignements sur le Médicament, Hôpital de Bellevue, 42055 Saint-Etienne, France.
Therapie. 2001 Jan-Feb;56(1):41-50.
Taste disorders, generally poorly studied, have various causes. From 1985 to 1997, 305 observations of taste disorders imputed to drugs were notified to Regional Pharmacovigilance Centres. Patients were on average 54.4 years old and 58 per cent were women. Quantitative as well as qualitative disorders have been observed. Drugs mainly found were: angiotensin converting enzyme inhibitors, terbinafine, zopiclone, D-penicillamine, imidazole derivatives, quinolones, macrolides, carbimazole and calcium channel blockers. The outcome was favourable for 60.3 per cent of patients. The possible efficacy of zinc is discussed. It is generally considered that taste disorders are not a serious side-effect, but they can reduce the quality of life and lead to poor compliance with treatment.
味觉障碍通常研究较少，其病因多种多样。1985年至1997年期间，向各地区药物警戒中心通报了305例归因于药物的味觉障碍观察病例。患者平均年龄为54.4岁，58%为女性。已观察到定量和定性障碍。主要发现的药物有：血管紧张素转换酶抑制剂、特比萘芬、佐匹克隆、D-青霉胺、咪唑衍生物、喹诺酮类、大环内酯类、卡比马唑和钙通道阻滞剂。60.3%的患者预后良好。文中讨论了锌的可能疗效。一般认为味觉障碍不是严重的副作用，但它们会降低生活质量并导致治疗依从性差。
