Mussini I, Sogos V, Della Barbera M, Ennas M G, Gremo F
Dept. of Biomedical Science, University of Padova, Italy.
Ital J Anat Embryol. 1995;100 Suppl 1:155-63.
Dystrophin, the product of the Duchenne muscular dystrophy gene, has been shown to be developmentally regulated in both human muscle and brain tissues. We consequently performed an immunocytochemical study using electron microscopy to localise the protein in the immature human fetal muscle and neurons. Results demonstrated that, even if dystrophin was partially associated to the plasma membrane in both tissues, some product was also linked to the neurofilaments network in neurons and to microfilaments in muscle. An intense staining was also found in satellite cells.
肌营养不良蛋白是杜兴氏肌营养不良症基因的产物，已被证明在人类肌肉和脑组织中受发育调控。因此，我们使用电子显微镜进行了一项免疫细胞化学研究，以在未成熟的人类胎儿肌肉和神经元中定位该蛋白。结果表明，即使肌营养不良蛋白在两种组织中都部分与质膜相关联，但在神经元中也有一些产物与神经丝网络相连，在肌肉中与微丝相连。在卫星细胞中也发现了强烈的染色。
