Pina M J, Pina J A
Department of Medicine of the Faculty of Medical Sciences of the New University of Lisbon and S. Francisco Xavier Hospital, Portugal.
Ital J Anat Embryol. 1995;100 Suppl 1:253-60.
This paper presents scanning electron microscopic features of T and B Lymphocytes in patients affected with AIDS and ARC and compares these results with others obtained in patients showing an immunodeficiencey associated with therapy for oncological diseases and in normal healthy donors. The SEM observations showed some surface alterations of the lymphocytes consisting in protrusions, buddings and characteristic "bowl-shaped" cavities particularly evident on the lymphocytes' surface of end stage patients suffering from AIDS. Similar aspects were not found in the other groups including the healthy donors. These lymphocyte surface alterations might likely correspond to the first sign of cell disfunction and therefore represent an early marker of this complex disease.
本文呈现了艾滋病（AIDS）和艾滋病相关综合征（ARC）患者T淋巴细胞和B淋巴细胞的扫描电子显微镜特征，并将这些结果与因肿瘤疾病治疗而出现免疫缺陷的患者以及正常健康供体的结果进行了比较。扫描电子显微镜观察显示，淋巴细胞存在一些表面改变，表现为突起、出芽以及特征性的“碗状”空洞，这在艾滋病晚期患者的淋巴细胞表面尤为明显。在包括健康供体在内的其他组中未发现类似情况。这些淋巴细胞表面改变可能对应细胞功能障碍的首个迹象，因此代表了这种复杂疾病的早期标志物。
