Jeong H J, Koo H N, Myung N I, Shin M K, Kim J W, Kim D K, Kim K S, Kim H M, Lee Y M
Department of Oriental Pharmacy, College of Pharmacy, and Center of Oriental Medicinal Science, Wonkwang University, Iksan, Chonbuk, Republic of Korea.
Immunopharmacol Immunotoxicol. 2001 Feb;23(1):107-17. doi: 10.1081/iph-100102572.
The crude drug "Siberian Ginseng (SG)" has long been used in empirical Oriental medicine for the nonspecific enhancement of resistance in humans and animals. In this study, we investigated the effect of cell cultured SG by oral administration in mast cell-mediated allergic reactions. SG dose-dependently inhibited compound 48/80-induced systemic allergy with doses of 10(-2) to 1 g/kg 1 h before oral administration. Of special note, SG inhibited systemic allergy with the dose of 1 g/kg by 25%. SG (1 g/kg) also inhibited passive cutaneous allergic reaction by 51%. SG dose-dependently inhibited histamine release from rat peritoneal mast cells. When SG (0.01 mg/ml) was added, the secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 in antidinitrophenyl (DNP) IgE antibody-stimulated mast cells was inhibited 39.5% and 23.3%, respectively. In addition, SG inhibited anti-DNP IgE antibody-stimulated TNF-alpha protein expression in mast cells. Our studies provide evidence that SG may be beneficial in the treatment of various types of allergic diseases.
生药“刺五加（SG）”长期以来一直被用于传统东方医学中，用于非特异性增强人和动物的抵抗力。在本研究中，我们研究了口服细胞培养的刺五加在肥大细胞介导的过敏反应中的作用。在口服前1小时，刺五加以10（-2）至1 g/kg的剂量剂量依赖性地抑制了化合物48/80诱导的全身过敏反应。特别值得注意的是，刺五加以1 g/kg的剂量抑制全身过敏反应达25%。刺五加（1 g/kg）还使被动皮肤过敏反应抑制了51%。刺五加剂量依赖性地抑制大鼠腹膜肥大细胞释放组胺。当加入刺五加（0.01 mg/ml）时，抗二硝基苯基（DNP）IgE抗体刺激的肥大细胞中肿瘤坏死因子-α（TNF-α）和白细胞介素-6的分泌分别被抑制了39.5%和23.3%。此外，刺五加抑制了肥大细胞中抗DNP IgE抗体刺激的TNF-α蛋白表达。我们的研究提供了证据，表明刺五加可能对治疗各种类型的过敏性疾病有益。
