Whole-body kinetics and dosimetry of cis-4-[(18)F]fluoro-L-proline.

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作者信息

Börner A R, Langen K J, Herzog H, Hamacher K, Müller-Mattheis V, Schmitz T, Ackermann R, Coenen H H

机构信息

Clinic of Nuclear Medicine, Heinrich-Heine-University Düsseldorf, FRG, Düsseldorf, Germany.

出版信息

Nucl Med Biol. 2001 Apr;28(3):287-92. doi: 10.1016/s0969-8051(00)00198-0.

DOI:10.1016/s0969-8051(00)00198-0

PMID:11323239

Abstract

The whole-body distribution of 4-cis[(18)F]fluoro-L-proline (cis-FPro) was studied in six patients with urological tumors by PET. Based on the IMEDOSE and MIRDOSE procedures radiation absorbed doses were estimated from whole-body PET scans acquired at 1 and 3-5 h after i.v. injection of 400 MBq cis-FPro. Cis-FPro showed high retention in the renal cortex and a slight uptake in liver and pancreas. Urinary excretion ranged from 12 to 19% at 5 h p.i. Highest absorbed doses were found for the urinary bladder wall and the kidneys (44.1/44.0 microGy/mbq). The effective dose according to ICRP 60 was 15.1 microSv/mbq for adults. This leads to an effective dose of 6.0 mSv in a PET study using 400 MBq cis-FPro.

摘要