患有呼吸道和非呼吸道疾病的婴幼儿的血液组胺水平（BHL）
Blood histamine levels (BHL) in infants and children with respiratory and non-respiratory diseases.
作者信息
Ponvert C, Galoppin L, Paupe J, de Blic J, Le Bourgeois M, Scheinmann P
机构信息
Department of Pediatrics, Pulmonology & Allergy Service, Sick Children Hospital, Paris, France.
出版信息
Mediators Inflamm. 2001 Feb;10(1):7-11. doi: 10.1080/09629350124382.
BACKGROUND
Blood histamine levels are decreased after severe allergic reactions and in various chronic diseases.
AIMS
To study blood histamine levels in infants and children with acute infectious and non-infectious, non-allergic, disease.
METHODS
Blood histamine levels were investigated by a fluorometric method in infants and children admitted to hospital with bronchiolitis, non-wheezing bronchitis, acute infections of the urinary tract, skin and ear-nose-throat, gastroenteritis, or hyperthermia of unknown aetiology. Results of blood histamine levels and white blood cell counts were compared with those obtained for children recovering from benign non-infectious, non-allergic illnesses.
RESULTS
As compared with control children, white blood cell numbers were significantly increased in children with acute infections of the urinary tract, skin and ear-nose-throat, and were significantly decreased in children with gastroenteritis. Blood histamine levels were significantly lower in children with gastroenteritis and hyperthermia than in children with other diseases and control children. It was not possible to correlate blood histamine levels and the number of blood basophils.
CONCLUSIONS
BHL are significantly decreased in infants and children with acute gastroenteritis and hyperthermia of unknown aetiology. The mechanisms responsible for the decrease in blood histamine levels in children with gastroenteritis and hyperthermia are discussed.
背景
严重过敏反应后以及在各种慢性疾病中，血液组胺水平会降低。
目的
研究患有急性感染性和非感染性、非过敏性疾病的婴幼儿和儿童的血液组胺水平。
方法
采用荧光法对因细支气管炎、非喘息性支气管炎、尿路感染、皮肤及耳鼻喉急性感染、肠胃炎或病因不明的发热而住院的婴幼儿和儿童的血液组胺水平进行研究。将血液组胺水平和白细胞计数的结果与从良性非感染性、非过敏性疾病中康复的儿童的结果进行比较。
结果
与对照儿童相比，尿路感染、皮肤及耳鼻喉急性感染患儿的白细胞数量显著增加，肠胃炎患儿的白细胞数量显著减少。肠胃炎和发热患儿的血液组胺水平显著低于其他疾病患儿和对照儿童。血液组胺水平与血液嗜碱性粒细胞数量之间无相关性。
结论
患有急性肠胃炎和病因不明发热的婴幼儿和儿童的血液组胺水平显著降低。文中讨论了肠胃炎和发热患儿血液组胺水平降低的机制。
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