Sand P G, Godau C, Riederer P, Peters C, Franke P, Nöthen M M, Stöber G, Fritze J, Maier W, Propping P, Lesch K P, Riess O, Sander T, Beckmann H, Deckert J
Department of Psychiatry, University of Würzburg, Germany.
Psychiatr Genet. 2000 Dec;10(4):191-4. doi: 10.1097/00041444-200010040-00007.
The enhancement of GABAergic neurotransmission has been closely linked to antipanic drug efficacy. This is the first study to investigate a putative association of exonic sequence variants of the human GABA(B) receptor 1 (GABA(B)R1) gene and susceptibility to panic disorder. Three DNA sequence variants in exons 1a1, 7 and 11 were assessed by polymerase chain reaction-based restriction fragment length polymorphism in a case-control study among patients with panic disorder with and without agoraphobia (DSM III-R criteria) and blood donors. There was no indication of an increased vulnerability to panic disorder or agoraphobia with respect to the allelic variants under study.
GABA能神经传递的增强与抗惊恐药物疗效密切相关。这是第一项研究人类GABA(B)受体1（GABA(B)R1）基因外显子序列变异与惊恐障碍易感性之间假定关联的研究。在一项病例对照研究中，通过基于聚合酶链反应的限制性片段长度多态性，对1a1、7和11号外显子中的三个DNA序列变异进行了评估，该研究的对象为有和没有广场恐惧症（DSM III-R标准）的惊恐障碍患者以及献血者。在所研究的等位基因变异方面，没有迹象表明惊恐障碍或广场恐惧症的易感性增加。
