呋喃类药物作为精子制动剂、其组织毒性及其在输精管结扎术中的临床应用。

The nitrofurans as sperm-immobilizing agents, their tissue toxicity, and their clinical application in vasectomy.

作者信息

Albert P S, Salerno R G, Kapoor S N, Davis J E

出版信息

Fertil Steril. 1975 Jun;26(6):485-91. doi: 10.1016/s0015-0282(16)41168-4.

Abstract

Nitrofurantoin sodium and nitorfurazone, in certain critical concentrations, have the ability to immobilize spermatozoa. In this study, this effect was consisitent with both 5:1, and 10:1 dilutions. Histologic examination of the effects of these drugs as intraoperative vas irrigants revealed no apparent tissue toxicity in the guinea pig. Clinically, we found intraoperative vas irrigation with both of these nontoxic drugs to be of value in attaining azoospermia immediately postvasectomy. Therefore, they appear to be useful supplements to vasectomy.

摘要

呋喃妥因钠和呋喃西林在某些临界浓度时具有使精子制动的能力。在本研究中，这种效应在5:1和10:1的稀释液中均一致。对这些药物作为术中输精管冲洗剂的作用进行组织学检查发现，在豚鼠中未显示出明显的组织毒性。临床上，我们发现用这两种无毒药物进行术中输精管冲洗对于输精管切除术后立即实现无精子症是有价值的。因此，它们似乎是输精管切除术的有用辅助手段。