Bugay D E
SSCI Inc., 3065 Kent Avenue, West Lafayette, IN 47906, USA.
Adv Drug Deliv Rev. 2001 May 16;48(1):43-65. doi: 10.1016/s0169-409x(01)00101-6.
The physical characterization of pharmaceutical solids is an integral aspect of the drug development process. This review summarizes the use of solid-state spectroscopy techniques used in the physical characterization of the active pharmaceutical ingredient, excipients, physical mixtures, and the final dosage form. A brief introduction to infrared, Raman, and solid-state NMR experimental techniques are described as well as a more thorough description of qualitative and quantitative applications. The use of solid-state imaging techniques such as IR, Raman, and TOF-SIMS is also introduced to the reader.
药物固体的物理表征是药物开发过程中不可或缺的一个方面。本综述总结了固态光谱技术在活性药物成分、辅料、物理混合物及最终剂型物理表征中的应用。文中简要介绍了红外、拉曼和固态核磁共振实验技术，并对定性和定量应用进行了更全面的描述。还向读者介绍了红外、拉曼和飞行时间二次离子质谱等固态成像技术的应用。
