Pagano L, Mele L, Voso M T, Chiusolo P, Putzulu R, Mazzotta S, Leone G
Haematologica. 2001 Apr;86(4):440-1.
A topotecan/cytarabine combination has been reported to be effective in patients with myelodysplastic syndromes. We report our experience with this regimen in 12 patients with relapsed or secondary acute myeloid leukemia. Extra-hematologic toxicity was low, but the response to the treatment was very poor. In our opinion, this association is not a treatment option for these patients, but the addition of other agents could improve this results.
据报道，拓扑替康与阿糖胞苷联合用药对骨髓增生异常综合征患者有效。我们报告了12例复发或继发性急性髓系白血病患者使用该方案的经验。血液学外毒性较低，但治疗反应非常差。我们认为，这种联合用药对这些患者并非一种治疗选择，但添加其他药物可能会改善结果。
