Lande M B, Thomas G A, Houghton D C
Department of Pediatrics, Division of Pediatric Nephrology, Children's Hospital at Strong, University of Rochester, Rochester, NY 14642, USA.
Am J Kidney Dis. 2001 May;37(5):E40. doi: 10.1016/s0272-6386(05)90004-8.
Membranous nephropathy has been associated with many autoimmune diseases. We describe a child with membranous nephropathy associated with chronic immune thrombocytopenic purpura (ITP) and Coombs'-positive hemolytic anemia. After 3 years of ITP, the patient developed nephrotic syndrome during a flare of ITP. A biopsy specimen showed membranous nephropathy. Treatment with corticosteroids led to improvement of the thrombocytopenia and resolution of the proteinuria. Two years later, the patient again developed thrombocytopenia and proteinuria. Both conditions resolved after treatment with corticosteroids. This case suggests that ITP can cause membranous nephropathy.
膜性肾病与多种自身免疫性疾病相关。我们描述了一名患有膜性肾病的儿童，该疾病与慢性免疫性血小板减少性紫癜（ITP）及抗人球蛋白试验阳性的溶血性贫血相关。在ITP发病3年后，患者在ITP发作期间出现了肾病综合征。活检标本显示为膜性肾病。使用糖皮质激素治疗后，血小板减少症得到改善，蛋白尿消失。两年后，患者再次出现血小板减少症和蛋白尿。使用糖皮质激素治疗后，这两种情况均得到缓解。该病例提示ITP可导致膜性肾病。
