Acs G, Acs P, Beckwith S M, Pitts R L, Clements E, Wong K, Verma A
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA.
Cancer Res. 2001 May 1;61(9):3561-5.
Erythropoietin (EPO) stimulates the growth of erythroblasts in the bone marrow (C. Lacombe and P. Mayeux, NEPHROL: DIAL: TRANSPLANT:, 14 (SUPPL: 2): 22-28, 1999). We report basal and hypoxia-stimulated expression of EPO and its receptor, EPOR, in human breast cancer cells, and we demonstrate EPO-stimulated tyrosine phosphorylation and the proliferation of these cells in vitro. In 50 clinical specimens of breast carcinoma, we report high levels of EPO and EPOR associated with malignant cells and tumor vasculature but not with normal breast, benign papilloma, or fibrocystic tissue. Hypoxic tumor regions display the highest levels of EPO and EPOR expression. Enhanced EPO signaling may contribute to the promotion of human cancer by tissue hypoxia.
促红细胞生成素（EPO）可刺激骨髓中红细胞前体细胞的生长（C. 拉孔布和P. 马约，《肾透析与移植》，14（增刊2）：22 - 28，1999年）。我们报告了促红细胞生成素及其受体EPOR在人乳腺癌细胞中的基础表达和低氧刺激表达，并证明了促红细胞生成素刺激的酪氨酸磷酸化以及这些细胞在体外的增殖。在50份乳腺癌临床标本中，我们报告促红细胞生成素和EPOR的高水平与恶性细胞及肿瘤脉管系统相关，但与正常乳腺、良性乳头状瘤或纤维囊性组织无关。低氧肿瘤区域促红细胞生成素和EPOR表达水平最高。促红细胞生成素信号增强可能通过组织低氧促进人类癌症的发展。
