二聚体L-多巴衍生物作为潜在的前药。
Dimeric L-dopa derivatives as potential prodrugs.
作者信息
Di Stefano A, Mosciatti B, Cingolani G M, Giorgioni G, Ricciutelli M, Cacciatore I, Sozio P, Claudi F
机构信息
Dipartimento di Scienze del Farmaco, Università G. D'Annunzio, Chieti, Italy.
出版信息
Bioorg Med Chem Lett. 2001 Apr 23;11(8):1085-8. doi: 10.1016/s0960-894x(01)00140-8.
Abstract
A series of dimeric derivatives (+)-1, and (+)-2, and (+)-3a-d of L-Dopa diacetyl esters was synthesized and evaluated as potential L-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of L-Dopa in human plasma was observed.
摘要
合成了一系列L-多巴二乙酰酯的二聚体衍生物（+）-1、（+）-2和（+）-3a - d，并将其作为具有改善理化性质的潜在L-多巴前药进行评估。所有新化合物在水性缓冲溶液（pH 1.3和7.4）中均表现出化学稳定性。在人血浆中观察到L-多巴的释放相对缓慢。
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