Smith P M, Ferguson A V
Department of Physiology, Queen's University, Kingston Ontario, Canada.
J Neuroendocrinol. 2001 May;13(5):467-71. doi: 10.1046/j.1365-2826.2001.00657.x.
Adrenomedullin is a recently discovered peptide involved in the control of fluid and electrolyte homeostasis and cardiovascular function through peripheral and central nervous system actions. The present study was undertaken to examine the cardiovascular effects of adrenomedullin microinjection directly into the paraventricular nucleus (PVN). Microinjection of adrenomedullin into the PVN of urethane anaesthetized male Sprague-Dawley rats resulted in site-specific, repeatable decreases in blood pressure. These hypotensive effects were found to be dose related, and were not mediated by activation of calcitonin gene-related peptide receptors. These data suggest that adrenomedullin influences cardiovascular regulation through receptor mediated actions at the PVN of the hypothalamus.
肾上腺髓质素是一种最近发现的肽，它通过外周和中枢神经系统的作用参与体液和电解质平衡以及心血管功能的调节。本研究旨在探讨直接向室旁核（PVN）微量注射肾上腺髓质素对心血管的影响。向经乌拉坦麻醉的雄性Sprague-Dawley大鼠的PVN微量注射肾上腺髓质素，导致血压出现位点特异性、可重复的下降。这些降压作用呈剂量依赖性，且不是由降钙素基因相关肽受体的激活介导的。这些数据表明，肾上腺髓质素通过下丘脑室旁核的受体介导作用影响心血管调节。
