他克莫司谷浓度升高与霉酚酸酯所致腹泻相关：一例报告
Elevated tacrolimus trough levels in association with mycophenolate mofetil-induced diarrhea: a case report.
作者信息
Frühwirth M, Fischer H, Simma B, Ellemunter H
机构信息
Department of Pediatrics, University Hospital Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria.
出版信息
Pediatr Transplant. 2001 Apr;5(2):132-4. doi: 10.1034/j.1399-3046.2001.005002132.x.
The combination of tacrolimus (TAC) and mycophenolate mofetil (MMF) is frequently used for immunosuppression after organ transplantation (Tx), but the pharmacokinetics and interactions between the two drugs are poorly elucidated. We describe here the increase of TAC trough levels during MMF-induced diarrhea in a 8-yr-old boy after kidney Tx. Early dose reduction of TAC, together with short-term monitoring of TAC trough levels in the presence of diarrhea, is recommended.
他克莫司（TAC）与霉酚酸酯（MMF）联合常用于器官移植（Tx）后的免疫抑制，但这两种药物之间的药代动力学及相互作用尚未完全阐明。我们在此描述了一名8岁肾移植男孩在MMF诱导腹泻期间TAC谷浓度升高的情况。建议早期减少TAC剂量，并在腹泻期间对TAC谷浓度进行短期监测。
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