癫痫发作后用氯胺酮治疗后的正常空间记忆：选择性损伤减轻脑损伤啮齿动物的记忆缺陷。

Normal spatial memory following postseizure treatment with ketamine: selective damage attenuates memory deficits in brain-damaged rodents.

作者信息

Santi S A, Cook L L, Persinger M A, O'Connor R P

机构信息

Behavioral Neuroscience Laboratory, Laurentian University, Sudbury Ontario, Canada P3E 2C6.

出版信息

Int J Neurosci. 2001 Mar;107(1-2):63-75. doi: 10.3109/00207450109149757.

DOI:10.3109/00207450109149757

PMID:11328682

Abstract

Within 30 min after the initiation of status epilepticus (SE) by lithium and pilocarpine, rats were injected with either acepromazine or ketamine. Compared to the rats that had received the acepromazine, the group that had received the ketamine displayed more accurate spatial memory. Their scores did not differ significantly from normal (non-seized) controls. Although the ketamine treatment did not significantly change the amount of neuronal loss within about 100 Paxinos and Watson structures, it was neuroprotective for several structures within the thalamus and portions of the temporal and parietal cortices. Ketamine-treated rats, however, displayed markedly more damage within the entorhinal cortices and amygdalohippocampal area.

摘要

在用锂和毛果芸香碱引发癫痫持续状态（SE）后30分钟内，给大鼠注射乙酰丙嗪或氯胺酮。与接受乙酰丙嗪的大鼠相比，接受氯胺酮的组表现出更准确的空间记忆。它们的得分与正常（未发作）对照组没有显著差异。虽然氯胺酮治疗在约100个帕西诺斯和沃森结构内并未显著改变神经元损失的数量，但它对丘脑内的几个结构以及颞叶和顶叶皮质的部分区域具有神经保护作用。然而，氯胺酮治疗的大鼠在内嗅皮质和杏仁核海马区的损伤明显更多。