Krahe T E, Filgueiras C C, Caparelli-Dáquer E M, Schmidt S L
Laboratório de Neurofisiologia e Avaliação Neurocomportamental, Universidade do Estado do Rio de Janeiro (UERJ), Avenida Manoel de Abreu 444, 5 degrees andar, Fisiologia -Vila Isabel, Rio de Janeiro, RJ, Brazil, 20 551 170.
Int J Neurosci. 2001 Aug;108(1-2):21-30. doi: 10.3109/00207450108986502.
In the free-swimming rotatory test mice spend most of the time swimming close to the wall of the container attempting to escape from an aversive test situation. The attraction to the wall may suggest that turning behavior in the free-swimming test reflects the existence of intrinsic sensory asymmetries, which determine preferential attention adhesion to one side. In order to test this hypothesis, we investigated the rotatory swimming behavior of mice submitted to a unilateral hemispherectomy at adulthood, a condition of extreme sensory asymmetry. Fifteen days after surgery procedures, each mouse was tested for 5 min on 3 different days. We found that the hemispherectomized mice had a significant strong bias to turn in the direction contralateral to their lesion. These data could be explained considering that, in attempting to escape from the test situation, animals bring the recipient wall into their intact sensory field and, as a consequence, set the direction of locomotion. Thus, the free-swimming test may be useful to investigate sensory asymmetries during an aversive test situation.
在自由游泳旋转试验中，小鼠大部分时间都靠近容器壁游动，试图逃离厌恶的试验环境。对壁的吸引力可能表明，自由游泳试验中的转向行为反映了内在感觉不对称的存在，这种不对称决定了对一侧的优先注意力附着。为了验证这一假设，我们研究了成年后接受单侧大脑半球切除术的小鼠的旋转游泳行为，这是一种极端感觉不对称的情况。手术操作15天后，每只小鼠在3个不同的日子里接受5分钟的测试。我们发现，大脑半球切除的小鼠有明显强烈的偏向，朝着与损伤对侧的方向转动。考虑到在试图逃离试验环境时，动物会将接受壁带入其完整的感觉场，从而确定运动方向，这些数据可以得到解释。因此，自由游泳试验可能有助于研究厌恶试验环境中的感觉不对称。
