Bell I R, Baldwin C M, Stoltz E, Walsh B T, Schwartz G E
Department of Psychiatry, The University of Arizona College of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 84724, USA.
Int J Neurosci. 2001 Aug;108(1-2):31-42. doi: 10.3109/00207450108986503.
Patients with fibromyalgia (FM) have diffuse musculoskeletal pain; half report concomitant intolerance for low levels of environmental chemicals (CI). Previous investigators have hypothesized that the chronic pain and chemical intolerance reflect sensitization of different central nervous system limbic and/or mesolimbic reward pathways. We evaluated electroencephalographic (EEG) beta activity and blood glucose responses of FM patients with and without CI and normals during three repeated sucrose ingestion sessions and during a final, water-only session (testing for conditioning). The FM with CI exhibited oscillation (reversal in direction of change from session to session) at rest and then sensitization (progressive amplification) of EEG beta 1 over time across the 3 sucrose sessions versus controls. FM with CI showed sensitization of blood glucose over the 3 sucrose sessions, which, like the EEG findings, reverted toward baseline in the final water-only session. The data suggest that the subset of FM patients with CI have increased susceptibility to oscillation and physiological sensitization without conditioning, perhaps contributing to fluctuations in their chronic course.
纤维肌痛（FM）患者有弥漫性肌肉骨骼疼痛；半数患者报告同时对低水平环境化学物质不耐受（CI）。先前的研究人员推测，慢性疼痛和化学物质不耐受反映了不同中枢神经系统边缘和/或中脑边缘奖赏通路的敏化。我们评估了有CI和无CI的FM患者以及正常人在三次重复蔗糖摄入期间和最后一次仅饮水期间（条件测试）的脑电图（EEG）β活动和血糖反应。有CI的FM患者在静息时表现出振荡（各时段变化方向相反），然后在3次蔗糖摄入时段中，与对照组相比，EEG β1随时间逐渐敏化（逐渐放大）。有CI的FM患者在3次蔗糖摄入时段中血糖出现敏化，与EEG结果一样，在最后一次仅饮水时段恢复到基线水平。数据表明，有CI的FM患者亚组在未进行条件测试的情况下对振荡和生理敏化的易感性增加，这可能导致其慢性病程出现波动。
