牛磺酸可提高大鼠存活率，并减轻3-硝基丙酸所致的纹状体损伤。
Taurine increases rat survival and reduces striatal damage caused by 3-nitropropionic acid.
作者信息
Rivas-Arancibia S, Rodríguez A I, Zigova T, Willing A E, Brown W D, Cahill D W, Sanberg P R
机构信息
Dept. of Neurosurgery, College of Medicine, University of South Florida, Tampa, FL 33612, USA.
出版信息
Int J Neurosci. 2001 Aug;108(1-2):55-67. doi: 10.3109/00207450108986505.
Taurine acts as an antioxidant protecting neurons from free radical-mediated cellular damage. 3-nitropropionic acid (3-NP) inhibits energy metabolism, initiating oxidative stress. With the objective to examine whether taurine can protect glia and neurons from damage produced by 3-NP, male Wistar and Sprague-Dawley rats were treated with either (1) saline, (2) taurine (3) 3-NP and saline, or (4) 3-NP and taurine for 4 days. Survival was determined and brains were processed immunohistochemically. Large striatal lesions and increased GFAP, SOD, and taurine immunoreactivity were detected in the 3-NP group when compared with control groups. In contrast, animals receiving 3-NP and taurine exhibited less GFAP, SOD, and taurine immunoreactivity, along with increased survival rates. Results indicate that taurine treatment after 3-NP administration protects the striatum from damage.
牛磺酸作为一种抗氧化剂，可保护神经元免受自由基介导的细胞损伤。3-硝基丙酸（3-NP）抑制能量代谢，引发氧化应激。为了研究牛磺酸是否能保护神经胶质细胞和神经元免受3-NP产生的损伤，将雄性Wistar和Sprague-Dawley大鼠分为四组进行处理，分别为：（1）生理盐水组；（2）牛磺酸组；（3）3-NP与生理盐水组；（4）3-NP与牛磺酸组，处理4天。测定大鼠存活率，并对大脑进行免疫组织化学处理。与对照组相比，3-NP组出现大面积纹状体损伤，且胶质纤维酸性蛋白（GFAP）、超氧化物歧化酶（SOD）和牛磺酸免疫反应性增加。相反，接受3-NP和牛磺酸处理的动物，其GFAP、SOD和牛磺酸免疫反应性降低，存活率提高。结果表明，3-NP给药后给予牛磺酸治疗可保护纹状体免受损伤。
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