α-连环蛋白、β-连环蛋白和γ-连环蛋白的表达降低与非小细胞肺癌的高细胞增殖活性和低分化相关。
Reduced expression of alpha-catenin, beta-catenin, and gamma-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer.
作者信息
Pirinen R T, Hirvikoski P, Johansson R T, Hollmén S, Kosma V M
机构信息
Departments of Pathology and Forensic Medicine, University of Kuopio and Kuopio University Hospital, PO Box 1627, FIN-70211 Kuopio, Finland.
出版信息
J Clin Pathol. 2001 May;54(5):391-5. doi: 10.1136/jcp.54.5.391.
AIMS
To investigate the expression of catenins (alpha, beta, and gamma) in non-small cell lung carcinoma (NSCLC) and its relation to clinicopathological factors and prognosis.
METHODS
The expression of catenins was analysed immunohistochemically in 261 patients with resected NSCLC, diagnosed between 1978 and 1996 in eastern Finland: The cell proliferation index of the tumours was analysed by means of an image analyser. The staining results were compared with clinicopathological characteristics and survival.
RESULTS
Normal catenin staining was found significantly more often in adenocarcinomas than in squamous cell carcinomas or anaplastic/large cell carcinomas. Reduced staining of alpha-catenin, beta-catenin, and gamma-catenin was related to poor differentiation of the tumour. The tumours with reduced staining of beta-catenin or gamma-catenin often had higher cell proliferation activity. Nuclear staining of beta-catenin and gamma-catenin was found in 16 (7%) and 29 (13%) cases, respectively. This nuclear staining correlated directly with increased cell proliferation and inversely with membranous staining. In survival analyses the predictors of overall and disease free survival were stage and tumour type. The expression of catenins did not affect survival.
CONCLUSIONS
The expression of alpha-catenin, beta-catenin, and gamma-catenin is related to histological type and differentiation in NSCLC, although catenins have no independent prognostic value. However, this study supports the important role of the nuclear accumulation of beta-catenin and gamma-catenin in highly proliferative cells.
目的
研究连环蛋白（α、β和γ）在非小细胞肺癌（NSCLC）中的表达及其与临床病理因素和预后的关系。
方法
采用免疫组织化学方法分析1978年至1996年在芬兰东部接受手术切除的261例NSCLC患者中连环蛋白的表达：通过图像分析仪分析肿瘤的细胞增殖指数。将染色结果与临床病理特征和生存率进行比较。
结果
腺癌中正常连环蛋白染色的发生率显著高于鳞状细胞癌或间变性/大细胞癌。α-连环蛋白、β-连环蛋白和γ-连环蛋白染色减少与肿瘤分化差有关。β-连环蛋白或γ-连环蛋白染色减少的肿瘤通常具有较高的细胞增殖活性。分别在16例（7%）和29例（13%）病例中发现β-连环蛋白和γ-连环蛋白的核染色。这种核染色与细胞增殖增加直接相关，与膜染色呈负相关。在生存分析中，总生存和无病生存的预测因素是分期和肿瘤类型。连环蛋白的表达不影响生存率。
结论
α-连环蛋白、β-连环蛋白和γ-连环蛋白的表达与NSCLC的组织学类型和分化有关，尽管连环蛋白没有独立的预后价值。然而，本研究支持β-连环蛋白和γ-连环蛋白在高增殖细胞中的核积累的重要作用。
Zotero 插件