Nepomnyashchikh L M
Laboratory of General Pathological Anatomy, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Bull Exp Biol Med. 2001 Jan;131(1):6-14. doi: 10.1023/a:1017514109302.
Regenerative and plastic insufficiency of cardiomyocytes comprises cell changes resulting from impaired DNA-dependent RNA synthesis and biosynthetic processes. It is accompanied by progressive involution of cytoplasmic structures and causes atrophy and partial elimination of cells without signs of coagulation and colliquative necroses. Segregation and fragmentation of nucleoli in cardiomyocyte nuclei, lysis of myofibrils, and focal degradation of the cytoplasm are ultrastructural signs of impaired protein synthesis. Intracellular cardiomyocyte regeneration is characterized by disorientation of newly formed myofibrils and their excessive elongation, which are related to DNA damages followed by changes in transcription and translation in cardiomyocytes. Calculation of the absolute number of cardiomyocytes is a new approach to evaluation of contractile myocardial insufficiency.
心肌细胞的再生和塑性不足包括因DNA依赖性RNA合成和生物合成过程受损而导致的细胞变化。它伴随着细胞质结构的进行性退化，并导致细胞萎缩和部分消除，而无凝固性坏死和液化性坏死的迹象。心肌细胞核仁的分离和碎片化、肌原纤维的溶解以及细胞质的局灶性降解是蛋白质合成受损的超微结构特征。心肌细胞内再生的特征是新形成的肌原纤维排列紊乱及其过度伸长，这与DNA损伤以及随后心肌细胞转录和翻译的变化有关。计算心肌细胞的绝对数量是评估收缩性心肌功能不全的一种新方法。
