通过连锁不平衡进行精细尺度基因定位的年表。

A chronology of fine-scale gene mapping by linkage disequilibrium.

作者信息

Lazzeroni L C

机构信息

Biostatistics Division, Department of Health Research and Policy, Stanford University, Stanford, California 94305, USA.

出版信息

Stat Methods Med Res. 2001 Feb;10(1):57-76. doi: 10.1177/096228020101000104.

DOI:10.1177/096228020101000104

PMID:11329692

Abstract

The past decade produced several proposals for fine-scale gene mapping using linkage disequilibrium data. The suggested methods fall into two main groups, those that rely on pairwise statistics and those that rely on haplotypes. This paper reviews each strategy's development from a chronological perspective.

摘要

在过去十年里，出现了几项利用连锁不平衡数据进行精细基因定位的提议。所提出的方法主要分为两类，一类依赖于成对统计量，另一类依赖于单倍型。本文按时间顺序回顾了每种策略的发展情况。