[A型肉毒杆菌毒素对白化病和有色家兔虹膜括约肌及开大肌神经元诱发反应的突触前效应]
[Presynaptic effects of botulinum toxin type A on the neuronally evoked response of albino and pigmented rabbit iris sphincter and dilator muscles].
作者信息
Ishikawa H, Mitsui Y, Yoshitomi T, Mashimo K, Aoki S, Mukuno K, Shimizu K
机构信息
Department of Ophthalmology Kitasato University, School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Japan.
出版信息
Nippon Ganka Gakkai Zasshi. 2001 Apr;105(4):218-22.
PURPOSE
To investigate the effects of botulinum toxin type A(botulinum A toxin) on the autonomic and other non-adrenergic, non-cholinergic nerve terminals.
METHODS
The effects of neurotoxin on twitch contractions evoked by electrical field stimulation (EFS) were studied in isolated rabbit iris sphincter and dilator muscles using isometric tension recording.
RESULTS
Botulinum A toxin(150 nM) inhibited the fast cholinergic and slow substance P-ergic component of contraction evoked by EFS in the rabbit iris sphincter muscle without affecting the response to carbachol and substance P. Botulinum A toxin(150 nM) did not affect the twitch contraction evoked by EFS in the rabbit iris dilator muscle.
CONCLUSION
These data indicated that botulinum A toxin may inhibit not only the acetylcholine release in the cholinergic nerve terminals, but also substance P release from the trigeminal nerve terminals of the rabbit iris sphincter muscle. However, neurotoxin has little effect on the adrenergic nerve terminals of the rabbit iris dilator muscle.
目的
研究A型肉毒毒素对自主神经及其他非肾上腺素能、非胆碱能神经末梢的作用。
方法
采用等长张力记录法，研究神经毒素对离体兔虹膜括约肌和开大肌电场刺激（EFS）诱发的抽搐收缩的影响。
结果
150 nM的A型肉毒毒素抑制兔虹膜括约肌EFS诱发收缩的快速胆碱能和缓慢P物质能成分，而不影响对卡巴胆碱和P物质的反应。150 nM的A型肉毒毒素不影响兔虹膜开大肌EFS诱发的抽搐收缩。
结论
这些数据表明，A型肉毒毒素不仅可抑制胆碱能神经末梢释放乙酰胆碱，还可抑制兔虹膜括约肌三叉神经末梢释放P物质。然而，神经毒素对兔虹膜开大肌的肾上腺素能神经末梢几乎没有影响。
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