Ward E, Picton S
Dietetic Department, St James's University Hospital, Leeds, UK.
J Hum Nutr Diet. 2001 Apr;14(2):149-52. doi: 10.1046/j.1365-277x.2001.00279.x.
Persistent diarrhoea has recently been reported as a common problem following surgical resection for advanced abdominal neuroblastoma.
A 10-month-old child, who had previously had no nutritional problems whilst undergoing chemotherapy treatment for a stage IV neuroblastoma, developed severe diarrhoea following tumour resection. He required nutritional support and was commenced on a continuous overnight nasogastric feed of a non-milk protein hydrolysate feed (MCT Pepdite 0-2, S.H.S. International Ltd, UK) His diarrhoea persisted and it was assumed that this was a postoperative problem which in time would regress. Two months later the child was admitted with a rectal prolapse, and a colonoscopy and biopsy suggested allergic protocolitis. The diarrhoea resolved rapidly on stopping the feed.
Although he was never re-challenged with the non-milk protein hydrolysate, it appears that he had a rare intolerance to an extensively hydrolysed protein formula which was masked by the assumption that his diarrhoea was a postoperative problem.
近期有报道称，晚期腹部神经母细胞瘤手术切除后持续腹泻是一个常见问题。
一名10个月大的儿童，此前在接受IV期神经母细胞瘤化疗期间没有营养问题，但在肿瘤切除后出现了严重腹泻。他需要营养支持，并开始持续夜间鼻饲非乳蛋白水解配方奶粉（MCT Pepdite 0-2，英国S.H.S. International Ltd公司）。他的腹泻持续存在，当时认为这是一个术后问题，最终会自行缓解。两个月后，该儿童因直肠脱垂入院，结肠镜检查和活检提示过敏性直肠炎。停止喂食后腹泻迅速缓解。
尽管他从未再次使用非乳蛋白水解配方奶粉，但似乎他对一种深度水解蛋白配方奶粉存在罕见的不耐受，而这种不耐受被腹泻是术后问题的假设所掩盖。
