一株对氨苯砜、利福平、氧氟沙星和司帕沙星耐药的麻风分枝杆菌分离株。

A Mycobacterium leprae isolate resistant to dapsone, rifampin, ofloxacin and sparfloxacin.

作者信息

Matsuoka M, Kashiwabara Y, Namisato M

机构信息

Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aobacho, Higashimurayama-shi, 189-0002 Tokyo, Japan.

出版信息

Int J Lepr Other Mycobact Dis. 2000 Dec;68(4):452-5.

PMID:11332288

Abstract

Mycobacterium leprae were isolated from a Japanese patient, and susceptibility to antileprosy drugs was examined by the mouse foot pad method. The isolate was susceptible to clofazimine and clarithromycin, and resistant to dapsone, rifampin, ofloxacin and sparfloxacin. Mutations were identified in the genes associated with resistance to these drugs. The risk of the emergence of leprosy with multidrug resistance is emphasized.

摘要

从一名日本患者身上分离出了麻风分枝杆菌，并通过小鼠足垫法检测了其对抗麻风病药物的敏感性。该分离株对氯法齐明和克拉霉素敏感，对氨苯砜、利福平、氧氟沙星和司帕沙星耐药。在与这些药物耐药性相关的基因中发现了突变。强调了出现耐多药麻风病的风险。