通过比例杀菌试验测定司帕沙星对麻风分枝杆菌的活性。

Activity of sparfloxacin against Mycobacterium leprae measured by the proportional bactericidal test.

作者信息

McDermott-Lancaster R D, Banerjee D K

机构信息

Department of Medical Microbiology, St. George's Hospital Medical School, London, U.K.

出版信息

Int J Lepr Other Mycobact Dis. 1993 Dec;61(4):605-8.

PMID:8151193

Abstract

The activity of 25 mg/kg and 50 mg/kg sparfloxacin was measured against Mycobacterium leprae in normal (immunocompetent) mouse foot pads by the proportional bactericidal test. This was compared with the action of 25, 50, and 150 mg/kg ofloxacin by the same method. Sparfloxacin, at both concentrations, was found to be strongly bactericidal by this method, comparable to 150 mg/kg ofloxacin.

摘要

通过比例杀菌试验，在正常（免疫功能正常）小鼠足垫中测定了25毫克/千克和50毫克/千克司帕沙星对麻风分枝杆菌的活性。并采用相同方法将其与25、50和150毫克/千克氧氟沙星的作用进行比较。结果发现，两种浓度的司帕沙星通过该方法均具有很强的杀菌作用，与150毫克/千克氧氟沙星相当。