Brown S D, Landry F J
Department of Medicine, University of Vermont College of Medicine, and Fletcher Allen Health Care, Burlington, USA.
South Med J. 2001 Apr;94(4):370-3.
Adverse drug reactions (ADRs) are underreported and consequently are an underestimated cause of morbidity and mortality. Recent epidemiologic evidence estimates that ADRs represent the fourth to the sixth leading cause of death. Public awareness is increasing as reports of ADRs and medication errors become more prevalent in the lay press. Reducing the number of ADRs can be accomplished by systems changes made at an individual and national level. At the individual level, increased diligence should be used with regard to reporting and documenting ADRs. At the national level, ADRs can be reduced by expanding the role of the arm of the Food and Drug Administration (FDA) responsible for postmarketing surveillance.
药物不良反应（ADR）报告不足，因此是发病率和死亡率的一个被低估的原因。最近的流行病学证据估计，ADR是第四至第六大主要死因。随着ADR和用药错误的报告在大众媒体中越来越普遍，公众意识正在提高。减少ADR的数量可以通过个人和国家层面的系统变革来实现。在个人层面，应更加勤勉地报告和记录ADR。在国家层面，可以通过扩大食品药品监督管理局（FDA）负责上市后监测的部门的作用来减少ADR。
