Hendrich C E, Porterfield S P, Galton V A
Horm Metab Res. 1979 May;11(5):362-5. doi: 10.1055/s-0028-1092739.
Maternal hypothyroidism induced by surgical thyroidectomy (Tx) of the rat resulted in significantly higher fetal serum levels of thyroid stimulating hormone (TSH) and thyroxine (T4) on day 22 of gestation. Surprisingly, administration of growth hormone (GH) to hypothyroid mothers increased further the fetal serum T4 and TSH. The in vitro uptake of 131I-T4 by erythrocytes was elevated significantly when incubated with serum from fetuses of both hypothyroid and hypothyroid GH-treated mothers. Although the plasma protein levels of hypothyroid mothers and their fetuses are decreased significantly as compared to controls this is not true of hypothyroid GH-treated mothers and their fetuses. The T4 levels of both groups of Tx mothers were significantly below that of controls. However, as in the case of their fetuses, the serum T4 of GH-treated hypothyroid mothers was elevated from that of Tx only animals. It is concluded that the pituitary-thyroid system of fetuses of hypothyroid mothers is activated excessively during late gestation, that considerable T4 can be transported from the fetus to the mother during this period and that these fetuses are in fact born in a hyperthyroid state which is aggravated by maternal treatment with GH.
大鼠手术切除甲状腺（Tx）所致的母体甲状腺功能减退，导致妊娠第22天胎儿血清促甲状腺激素（TSH）和甲状腺素（T4）水平显著升高。令人惊讶的是，给甲状腺功能减退的母体注射生长激素（GH）会进一步提高胎儿血清T4和TSH水平。当与甲状腺功能减退和接受GH治疗的甲状腺功能减退母体的胎儿血清一起孵育时，红细胞对131I-T4的体外摄取显著升高。尽管与对照组相比，甲状腺功能减退母体及其胎儿的血浆蛋白水平显著降低，但接受GH治疗的甲状腺功能减退母体及其胎儿并非如此。两组Tx母体的T4水平均显著低于对照组。然而，与其胎儿的情况一样，接受GH治疗的甲状腺功能减退母体的血清T4水平比仅接受Tx的动物有所升高。得出的结论是，甲状腺功能减退母体的胎儿垂体-甲状腺系统在妊娠后期被过度激活，在此期间相当数量的T4可从胎儿转运至母体，并且这些胎儿实际上出生时处于甲状腺功能亢进状态，而母体用GH治疗会使其加重。
