肺炎支原体与肺泡巨噬细胞的相互作用：黏附及摄入的支原体的生存能力
Interaction of Mycoplasma pneumoniae with alveolar macrophages: viability of adherent and ingested mycoplasmas.
作者信息
Erb P, Bredt W
出版信息
Infect Immun. 1979 Jul;25(1):11-5. doi: 10.1128/iai.25.1.11-15.1979.
Abstract
Guinea pig peritoneal or alveolar macrophages were inoculated with Mycoplasma pneumoniae cells. Extracellular mycoplasms were killed by complement treatment, and the effect of macrophage action on the number of the remaining viable mycoplasmas was observed. The complement killing was to some extent inhibited by the presence of the macrophages, but the mechanism of this protection remains unknown. Opsonized mycoplasmas were ingested, and approximately 98% were killed within 4 h. The killing rate was somewhat lower than comparable data for bacteria, but lack of cell wall and high lipid content of the membrane apparently do not cause a significant delay in intracellular destruction.
摘要
将肺炎支原体细胞接种到豚鼠腹腔或肺泡巨噬细胞中。通过补体处理杀死细胞外支原体，并观察巨噬细胞作用对剩余存活支原体数量的影响。巨噬细胞的存在在一定程度上抑制了补体杀伤作用，但其保护机制尚不清楚。调理过的支原体被吞噬，约98%在4小时内被杀死。杀伤率略低于细菌的可比数据，但缺乏细胞壁和细胞膜脂质含量高显然不会导致细胞内破坏显著延迟。
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Phagocytosis by macrophages of mycoplasma pneumoniae after opsonization by complement.肺炎支原体经补体调理后被巨噬细胞吞噬。
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9
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