Schild A L, Riet-Correa F, Portiansky E L, Méndez M C, Graça D L
Laboratório Regional de Diagnóstico, Faculdade de Veterinária, UFPel, RS, Brazil.
Vet Res Commun. 2001 Apr;25(3):189-95. doi: 10.1023/a:1006477508776.
A congenital progressive cerebellar disorder is described in Holstein calves. The clinical signs were progressive and were characterized by ataxia, hypermetria, a wide stance and fine head tremors. When the affected cattle were forced to run, the signs were exacerbated, leading to epileptiform attacks. Histological lesions consisted of a very selective cerebellar cortical degeneration, almost exclusively affecting the Purkinje cells. The disease affected 6 out of 200 Holstein calves from the same bull. However, results of mating tests of the bull with his daughters and granddaughters suggested that it was not hereditary (p = 0.0062) although an environmental-genetic interaction could not be ruled out.
荷斯坦犊牛中描述了一种先天性进行性小脑疾病。临床症状呈进行性，特征为共济失调、动作过度、站立姿势宽以及头部细微震颤。当患牛被迫奔跑时，症状会加重，导致癫痫样发作。组织学病变表现为非常选择性的小脑皮质变性，几乎仅影响浦肯野细胞。该疾病在同一头公牛的200头荷斯坦犊牛中有6头发病。然而，该公牛与其女儿和孙女的交配试验结果表明，尽管不能排除环境 - 基因相互作用，但它不是遗传性的（p = 0.0062）。
