来自哈氏德氏豆的异戊烯基黄酮类化合物及其在德氏豆属中的系统学意义

Prenylated flavonoids from Deguelia hatschbachii and their systematic significance in Deguelia.

作者信息

Magalhães A F, Tozzi A M, Magalha s E G, de Souza Moraes V R

机构信息

Departamento de Química Orgânica, Instituto de Química, UNICAMP, Campinas, São Paulo, Brazil.

出版信息

Phytochemistry. 2001 May;57(1):77-89. doi: 10.1016/s0031-9422(00)00509-4.

DOI:10.1016/s0031-9422(00)00509-4

PMID:11336265

Abstract

Chemical investigation of dichloromethane and petrol extracts from the roots of D. hatshbachii A. M. G. Azevedo furnished thirteen compounds from which five are described for the first time and their structures were determined to be 3-(4'-hydroxyphenyl)-5-methoxy-6-( 3,3-dimethylallyl)-2"2"-dimethylchromene-(5",6":8,7)-3-(propyl-2-one)-4H-1-benzo-2,3-dihydropyran-2,4-dione; 6,4'-dihydroxy-3-(3,3-dimethylallyl)-2",2"-dimethylchromene (5",6":5,4)-2-methoxy deoxybenzoin; 6.4'-dihydroxy-3-(3,3-dimethylallyl)-2",2"-dimethylchromene (5",6":5,4)-2-methoxy-8-(propyl-2-one) deoxybenzon; 6-(3,3-dimethylallyl)-2",2"-dimethylchromene (5",6":4.5)-4'-hydroxy-3-methoxy stilbene and 3,5-dimethoxy-4'-hydroxy-4-(3,3-dimethylallyl) stilbene by spectral analysis (UV, IR, MS and ID- and 2D- NMR experiments). The root extracts and some isolated compounds were bioactive, as revealed by bioautography and brine shrimp lethality assays.

摘要

对哈茨巴赫地锦（D. hatshbachii A. M. G. Azevedo）根部的二氯甲烷和石油醚提取物进行化学研究，从中分离出13种化合物，其中5种为首次报道。通过光谱分析（紫外光谱、红外光谱、质谱以及一维和二维核磁共振实验）确定它们的结构分别为：3-(4'-羟基苯基)-5-甲氧基-6-(3,3-二甲基烯丙基)-2",2"-二甲基色烯-(5",6":8,7)-3-(丙-2-酮)-4H-1-苯并-2,3-二氢吡喃-2,4-二酮；6,4'-二羟基-3-(3,3-二甲基烯丙基)-2",2"-二甲基色烯(5",6":5,4)-2-甲氧基脱氧安息香；6,4'-二羟基-3-(3,3-二甲基烯丙基)-2",2"-二甲基色烯(5",6":5,4)-2-甲氧基-8-(丙-2-酮)脱氧安息香；6-(3,3-二甲基烯丙基)-2",2"-二甲基色烯(5",6":4,5)-4'-羟基-3-甲氧基芪；3,5-二甲氧基-4'-羟基-4-(3,3-二甲基烯丙基)芪。生物自显影和卤虫致死试验表明，根部提取物和一些分离得到的化合物具有生物活性。