Blondeau J M, Hansen G T
Department of Clinical Microbiology, Royal University Hospital and the University of Saskatchewan, 103 Hospital Drive, Saskatoon, Saskatchewan S7N 0W8, Canada.
Expert Opin Pharmacother. 2001 Feb;2(2):317-35. doi: 10.1517/14656566.2.2.317.
Antimicrobial agents are used to treat patients with infectious diseases. Initial antimicrobial compounds originated from natural sources and were generally deemed to be narrow in spectrum. Today, we are in the era of designer drugs that have been specifically developed with current issues in infectious diseases in mind. For example, some new compounds require once daily dosing, have minimal side effects, are active against resistant pathogens and, for some, have a lower propensity for selecting for antimicrobial resistance during patient therapy.
抗菌药物用于治疗传染病患者。最初的抗菌化合物来源于天然物质,其抗菌谱通常较窄。如今,我们正处于专门针对当前传染病问题研发的设计药物时代。例如,一些新化合物只需每日给药一次,副作用极小,对耐药病原体具有活性,而且其中一些在患者治疗期间产生抗菌耐药性的倾向较低。