Lorenzato F, Singer A, Mould T, Santos L C, Maia A, Cariri L
Department of Gynecology and Obstetrics, Instituto Materno-Infantil de Pernambuco (IMIP), Recife, PE, Brazil.
Int J Gynaecol Obstet. 2001 Apr;73(1):41-6. doi: 10.1016/s0020-7292(00)00390-8.
The city of Recife, northeastern Brazil, is reported to have the highest incidence of cervical cancer worldwide (83.2/100000 women).
To evaluate the efficacy of Hybrid Capture I (HC I) in cervical cancer detection and some risk factors in Recife.
Cervical scrapes for HC I analysis followed by colposcopy were collected from 140 women (70 with cervical cancer and 70 with normal cervix) from three screening services in Recife.
HC I sensitivity and specificity were 82.9 and 41.4%, respectively. The odds ratios for cervical cancer when Gesta > or = 5 and vaginal parity > or = 4 were, respectively, 5.30 and 4.27.
HC I is a moderately sensitive method to detect cervical cancer, but it does not seem to be useful as a primary screening tool for it's low specificity. Early pregnancy, high Gesta/Para and living in rural areas were important local risk factors.
据报道，巴西东北部累西腓市的宫颈癌发病率为全球最高（每10万名女性中有83.2例）。
评估杂交捕获I代（HC I）在累西腓市宫颈癌检测中的效果以及一些风险因素。
从累西腓市三个筛查机构的140名女性（70例宫颈癌患者和70例宫颈正常女性）中收集用于HC I分析的宫颈刮片，随后进行阴道镜检查。
HC I的敏感性和特异性分别为82.9%和41.4%。妊娠次数≥5次和经产次数≥4次时患宫颈癌的优势比分别为5.30和4.27。
HC I是检测宫颈癌的一种中度敏感方法，但因其特异性较低，似乎不宜作为主要筛查工具。早孕、高妊娠次数/经产次数以及居住在农村地区是重要的局部风险因素。
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