Yalkowsky S H, Amidon G L, Zografi G, Flynn G L
J Pharm Sci. 1975 Jan;64(1):48-52. doi: 10.1002/jps.2600640109.
The relative solubilities of n-alkyl p-aminobenzoates in water, proplyene blycol-water mixtures, proplyene glycol, and several other pharmaceutically important solvents can be predicted on the basis of a theoretical equation. This equation relates the activity coefficient of the hydrophobic portion of the molecule to the product of its surface area and its interfacial tension [free energy per unit area of a hydrocarbon (tetradecane) against the polar or semipolar solvent of interest]. The assumptions, conclusions, and applicability of the theorectical relationship are compared to those of the Scatchard-Hildebrand approach.
基于一个理论方程，可以预测对氨基苯甲酸正烷基酯在水、丙二醇 - 水混合物、丙二醇以及其他几种重要药用溶剂中的相对溶解度。该方程将分子疏水部分的活度系数与其表面积和界面张力的乘积相关联[碳氢化合物（十四烷）相对于目标极性或半极性溶剂的单位面积自由能]。将该理论关系的假设、结论和适用性与斯卡查德 - 希尔德布兰德方法的进行了比较。
