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高效液相色谱法测定磺胺醋酰钠滴眼液

Assay of sulfacetamide sodium ophthalmic solutions by high-pressure liquid chromatography.

作者信息

Penner M H

出版信息

J Pharm Sci. 1975 Jun;64(6):1017-9. doi: 10.1002/jps.2600640629.

DOI:10.1002/jps.2600640629
PMID:1133718
Abstract

A high-pressure liquid chromatographic method, using an absorption column and sulfabenzamide as the internal standard, is proposed for the determination of sulfacetamide sodium and its principal hydrolysis product, sulfanilamide, in eye drops. It affords an average recovery of 100.9% of added sodium sulfacetamide with a relative standard deviation of 1.9%.

摘要

本文提出了一种高压液相色谱法,该方法使用吸收柱并以磺胺苯甲酰胺作为内标,用于测定滴眼液中的磺胺醋酰钠及其主要水解产物磺胺。添加的磺胺醋酰钠的平均回收率为100.9%,相对标准偏差为1.9%。

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