Miki K, Kubota K, Inoue Y, Vera D R, Makuuchi M
Department of Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
J Nucl Med. 2001 May;42(5):733-7.
Kinetic modeling of 99mTc-diethylenetriaminepentaacetic acid galactosyl human serum albumin (Tc-GSA) measures the total amount of asialoglycoprotein receptor within a subject's liver. This study tested the hypothesis that the amount of asialoglycoprotein receptor measured by Tc-GSA modeling provides a valid index of functional liver mass.
Twenty-two patients with cirrhosis, 18 patients with chronic hepatitis, and 9 patients with normal liver parenchyma were studied with Tc-GSA using a 30-min dynamic imaging protocol. The total amount of hepatic receptor was measured by kinetic modeling of the Tc-GSA time-activity data. The total number of viable hepatocytes was calculated using standard morphometric measurements of liver biopsy samples and liver volume measurements through CT.
The total receptor amount strongly correlated with the total hepatocyte number (r = 0.803; P < 0.0001).
Tc-GSA measurement of the total receptor amount is proportional to the number of viable hepatocytes and therefore provides a valid assessment of functional liver mass.
99mTc-二乙烯三胺五乙酸半乳糖基人血清白蛋白（Tc-GSA）的动力学模型可测量受试者肝脏内去唾液酸糖蛋白受体的总量。本研究检验了以下假设：通过Tc-GSA模型测量的去唾液酸糖蛋白受体量可作为功能性肝质量的有效指标。
采用30分钟动态成像方案，对22例肝硬化患者、18例慢性肝炎患者和9例肝实质正常的患者进行了Tc-GSA研究。通过对Tc-GSA时间-活性数据进行动力学建模来测量肝脏受体的总量。使用肝活检样本的标准形态测量方法和通过CT测量的肝脏体积来计算存活肝细胞的总数。
受体总量与肝细胞总数密切相关（r = 0.803；P < 0.0001）。
Tc-GSA测量的受体总量与存活肝细胞数量成正比，因此可有效评估功能性肝质量。
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