使用动态H2(15)O正电子发射断层扫描（PET）和因子分析对局部心肌血流量进行定量分析。

Quantification of regional myocardial blood flow using dynamic H2(15)O PET and factor analysis.

作者信息

Ahn J Y, Lee D S, Lee J S, Kim S K, Cheon G J, Yeo J S, Shin S A, Chung J K, Lee M C

机构信息

Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.

出版信息

J Nucl Med. 2001 May;42(5):782-7.

PMID:11337577

Abstract

UNLABELLED

Because the use of factor analysis has been proposed for extracting pure physiologic temporal or spatial information from dynamic nuclear medicine images, factor analysis should be capable of robustly estimating regional myocardial blood flow (rMBF) using H2(15)O PET without additional C15O PET, which is a cumbersome procedure for patients. Therefore, we measured rMBF using time-activity curves (TACs) obtained from factor analysis of dynamic myocardial H2(15)O PET images without the aid of C15O PET.

METHODS

H2(15)O PET of six healthy dogs at rest and during stress was performed simultaneously with microsphere studies using 85Sr, 46Sc, and 113SN: We performed factor analysis in two steps after reorienting and masking the images to include only the cardiac region. The first step discriminated each factor in the spatial distribution and acquired the input functions, and the second step extracted regional-tissue TACS: Image-derived input functions obtained by factor analysis were compared with those obtained by the sampling method. rMBF calculated using a compartmental model with tissue TACs from the second step of the factor analysis was compared with rMBF measured by microsphere studies.

RESULTS

Factor analysis was successful for all the dynamic H2(15)O PET images. The input functions obtained by factor analysis were nearly equal to those obtained by arterial blood sampling, except for the expected delay. The correlation between rMBF obtained by factor analysis and rMBF obtained by microsphere studies was good (r = 0.95). The correlation between rMBF obtained by the region-of-interest method and rMBF obtained by microsphere studies was also good (r = 0.93).

CONCLUSION

rMBF can be measured robustly by factor analysis using dynamic myocardial H2(15)O PET images without additional C15O blood-pool PET.

摘要

未标记

由于已有人提出使用因子分析从动态核医学图像中提取纯生理时间或空间信息，因此因子分析应能够在不进行额外的(C^{15}O)正电子发射断层扫描（PET）的情况下，使用(H_2^{15}O)PET稳健地估计局部心肌血流量（rMBF），而(C^{15}O)PET对患者来说是一个繁琐的过程。因此，我们在不借助(C^{15}O)PET的情况下，使用从动态心肌(H_2^{15}O)PET图像的因子分析中获得的时间-活性曲线（TAC）来测量rMBF。

方法

对6只健康犬在静息和应激状态下进行(H_2^{15}O)PET检查，并同时使用(^{85}Sr)、(^{46}Sc)和(^{113}Sn)进行微球研究：在对图像进行重新定位和屏蔽以仅包括心脏区域后，我们分两步进行因子分析。第一步在空间分布中区分每个因子并获取输入函数，第二步提取局部组织TAC：将通过因子分析获得的图像衍生输入函数与通过采样方法获得的输入函数进行比较。将使用来自因子分析第二步的组织TAC的房室模型计算的rMBF与通过微球研究测量的rMBF进行比较。

结果

因子分析对所有动态(H_2^{15}O)PET图像均成功。除了预期的延迟外，通过因子分析获得的输入函数几乎与通过动脉血采样获得的输入函数相等。通过因子分析获得的rMBF与通过微球研究获得的rMBF之间的相关性良好（r = 0.95）。通过感兴趣区域方法获得的rMBF与通过微球研究获得的rMBF之间的相关性也良好（r = 0.93）。