Jedrychowski W, Flak E, Mróz E
Katedra Epidemiologii i Medycyny Zapobiegawczej Collegium Medicum UJ 31-034 Kraków, ul. Kopernika 7.
Folia Med Cracov. 2000;41(3-4):25-33.
The epidemiologic study has been carried out in the sample of 1048 schoolchildren at the age of 11 years in order to assess the impact of various chronic respiratory symptoms on lung function. The symptoms included chronic dry cough, chronic phlegm, attacks of cough at nights, breathlessness, wheezing independent from respiratory infections or colds, attacks of wheezing at nights, and attacks of dyspnea with wheezing. Lung function was measured by the following spirometric indices: FEV1/FVC%, FEV1, FEF25-75% and PEFR. Multiple regression analysis showed strong statistical inverse relationship between FEV1/FVC% and FEF25-75% and attacks of wheezing at night and attacks of dyspnea with wheezing or asthma diagnosed by physician. The separate analysis performed in the subsample of children without asthma and asthmatic symptoms (attacks of wheezing at night and attacks of dyspnea with wheezing) found out that only chronic dry cough was related significantly to the lower values of FEV1 and PEFR in the children.
为评估各种慢性呼吸道症状对肺功能的影响，对1048名11岁学童样本进行了流行病学研究。这些症状包括慢性干咳、慢性咳痰、夜间咳嗽发作、呼吸急促、与呼吸道感染或感冒无关的喘息、夜间喘息发作以及伴有喘息的呼吸困难发作。通过以下肺量计指标测量肺功能：第一秒用力呼气容积/用力肺活量百分比（FEV1/FVC%）、第一秒用力呼气容积（FEV1）、25%-75%用力呼气流量（FEF25-75%）和呼气峰值流速（PEFR）。多元回归分析显示，FEV1/FVC%和FEF25-75%与夜间喘息发作以及医生诊断的伴有喘息的呼吸困难发作或哮喘之间存在强烈的统计学负相关。在无哮喘和哮喘症状（夜间喘息发作和伴有喘息的呼吸困难发作）的儿童子样本中进行的单独分析发现，只有慢性干咳与儿童较低的FEV1和PEFR值显著相关。
