Jankowski A, Jankowska B, Niedworok J
Zakład Organizacji Ochrony Zdrowia Wojsk i Zarzadzania w Słuzbie Zdrowia Wojskowa Akademia Medyczna ul. Zeligowskiego 7/9, 94-752 Łódź.
Folia Med Cracov. 2000;41(3-4):5-15.
In the work an effect of anthocyanins of red wine type Cabernet on the course and intensity of symptoms of the experimental diabetes in the rats has been examined. The estimation of the course of experimental diabetes was based on: determination of sugar concentration in urine and blood serum, determination of concentration of the unsaturated fatty acids peroxidation in urine and blood serum, also on the change of body mass during the experiment. The examination was carried out on 80, weighing 200-250 g, rats. They lived in the animal quarters with a stable temperature and humidity being fed with standard fodder (Murigan) with water supply in ever quantity. The rats were divided into the following four group: I--control group, II--group of animals receiving intraperitoneal streptozotocin in concentration 70 mg/kg m.c., III--group of animals receiving intragastric 10 mg/kg m.c. of natural anthocyanin dye of red wine type Cabernet, IV--group of animals receiving intraperitoneal 70 mg/kg m.c. of streptozotocin and simultaneously receiving intragastric 1 mg/kg m.c. of natural anthocyanin dye. An essential increase of glucose concentration in urine was found in the rats after streptozotocin injection. A simultaneous daily administration of anthocyanins obtained from red wine type Cabernet and streptozotocin substantially decreased sugar concentration in urine and blood serum. Those anthocyanins also inhibited loss of body mass caused by the former injection of streptozotocin. Simultaneously antocyan pigment was stated to considerably prevent generation of free oxygen radicals. The decrease of peroxidation of lipids, the measure of which was lowering of the concentration of the products of unsaturated fatty acids oxidation in urine and blood serum was also observed.
在这项研究中，检测了赤霞珠型红葡萄酒中的花青素对大鼠实验性糖尿病病程及症状严重程度的影响。实验性糖尿病病程的评估基于：测定尿液和血清中的糖浓度、尿液和血清中不饱和脂肪酸过氧化浓度，以及实验期间体重的变化。对80只体重在200 - 250克的大鼠进行了检测。它们生活在温度和湿度稳定的动物饲养室，喂食标准饲料（Murigan）并随时供应饮水。大鼠被分为以下四组：I组——对照组；II组——腹腔注射浓度为70毫克/千克体重的链脲佐菌素的动物组；III组——胃内给予10毫克/千克体重赤霞珠型红葡萄酒天然花青素染料的动物组；IV组——腹腔注射70毫克/千克体重链脲佐菌素且同时胃内给予1毫克/千克体重赤霞珠型红葡萄酒天然花青素染料的动物组。注射链脲佐菌素后，大鼠尿液中的葡萄糖浓度显著升高。同时每日给予赤霞珠型红葡萄酒中的花青素和链脲佐菌素，可使尿液和血清中的糖浓度大幅降低。这些花青素还抑制了先前注射链脲佐菌素导致的体重减轻。同时，花青素色素被证明能显著预防自由基的产生。还观察到脂质过氧化的减少，其衡量指标是尿液和血清中不饱和脂肪酸氧化产物浓度的降低。
