Abdulla H M
University of South Florida and James A. Haley VA Hospital, Division of Nephrology and Hypertension, Tampa, Florida 33612, USA.
Med Hypotheses. 2001 Apr;56(4):451-3. doi: 10.1054/mehy.2000.1230.
Since the discovery of the natriuretic effect of atrial natriuretic peptide (ANP), a family of other natriuretic peptides similar to ANP were isolated, including atriopeptin, vessel dilator, long-acting natriuretic peptide, urodilatin, and brain natriuretic peptide (BNP) to name a few. ANP was noted to possess natriuretic and diuretic properties that controlled increases in intravascular volume. ANP was also found to be elevated in conditions of increased intraocular pressure and biliary obstruction. BNP was found to be elevated in conditions of increased intracranial pressure, pointing towards its role in controlling cerebrospinal fluid volume. While at the cellular level, ANP controlled individual cell size. This makes the natriuretic peptides not only controllers of intravascular volume, but also modulators of a myriad of cavity volumes down to the control of individual cell volume.
自从发现心房利钠肽（ANP）的利钠作用以来，人们分离出了一系列与ANP相似的其他利钠肽，包括心钠素、血管舒张素、长效利钠肽、尿钠素和脑利钠肽（BNP）等。人们注意到ANP具有控制血管内容量增加的利钠和利尿特性。还发现ANP在眼压升高和胆道梗阻的情况下会升高。发现BNP在颅内压升高的情况下会升高，这表明它在控制脑脊液容量方面发挥作用。而在细胞水平上，ANP控制单个细胞的大小。这使得利钠肽不仅是血管内容量的控制者，也是从控制单个细胞体积到众多腔室体积的调节剂。
