Tavi P, Laine M, Weckström M, Ruskoaho H
Department of Physiology, Division of Biophysics, Biocenter Oulu, FIN-90014, University of Oulu, Finland.
Trends Pharmacol Sci. 2001 May;22(5):254-60. doi: 10.1016/s0165-6147(00)01679-5.
In heart muscle a mechanical stimulus is sensed and transformed into adaptive changes in cardiac function by a process called mechanotransduction. Adaptation of heart muscle to mechanical load consists of neurohumoral activation and growth, both of which decrease the initial load. Under prolonged overload this process becomes maladaptive, leading to the development of left ventricular hypertrophy and ultimately to heart failure. Widespread synergism and crosstalk among a variety of molecules and signals involved in hypertrophic signaling pathways make the prevention or treatment of left ventricular hypertrophy and heart failure a challenging task. Therapeutic strategies should include either a complete and continuous reduction of load or normalization of left ventricular mass by interventions aimed at specific targets involved in mechanotransduction.
在心肌中，机械刺激通过一种称为机械转导的过程被感知并转化为心脏功能的适应性变化。心肌对机械负荷的适应包括神经体液激活和生长，这两者都会降低初始负荷。在长期过载情况下，这个过程会变得适应不良，导致左心室肥厚的发展，并最终导致心力衰竭。参与肥厚信号通路的各种分子和信号之间广泛的协同作用和相互作用，使得预防或治疗左心室肥厚和心力衰竭成为一项具有挑战性的任务。治疗策略应包括通过针对参与机械转导的特定靶点的干预措施，完全且持续地减轻负荷或使左心室质量恢复正常。
