van Rijt L S, Lambrecht B N
Department of Pulmonary and Critical Care Medicine, Erasmus Medical Center Rotterdam, 3015 GE Rotterdam, The Netherlands.
Microsc Res Tech. 2001 May 15;53(4):256-72. doi: 10.1002/jemt.1092.
Asthma is a chronic disorder of the airways characterized by variable airway narrowing, mucus hypersecretion, and infiltration of the airway wall with eosinophils. It is now believed that asthma is controlled by Th2 lymphocytes producing cytokines such as IL-4, IL-5, IL-9, and IL-13. Animal models of eosinophilic airway inflammation and airway hyperreactivity have been developed to study the contribution of cells or mediators in the pathogenesis of asthma. In this review, we discuss the role of antigen presenting cells, CD4(+) and CD8(+) T lymphocytes, B lymphocytes, NK cells, and mast cells in the induction and maintenance of eosinophilic airway inflammation, mucus hypersecretion, and airway hyperreactivity.
哮喘是一种气道慢性疾病，其特征为气道可变狭窄、黏液分泌过多以及气道壁嗜酸性粒细胞浸润。目前认为，哮喘由产生白细胞介素-4、白细胞介素-5、白细胞介素-9和白细胞介素-13等细胞因子的辅助性T2淋巴细胞控制。已经建立了嗜酸性气道炎症和气道高反应性的动物模型，以研究细胞或介质在哮喘发病机制中的作用。在本综述中，我们讨论抗原呈递细胞、CD4(+)和CD8(+) T淋巴细胞、B淋巴细胞、自然杀伤细胞和肥大细胞在嗜酸性气道炎症、黏液分泌过多和气道高反应性的诱导和维持中的作用。
