Rosen E
Medical Dept. B, Hillel Yaffe Hospital, Hadera.
Harefuah. 2000 Dec;139(11-12):438-40, 494.
Eosinophilic pneumonia is a rare adverse effect of minocycline. To date there are about 70 chemical compounds that cause drug-induced, eosinophilic lung disease. A 20-year-old woman who developed eosinophilic pneumonia due to minocycline is described. Diagnosis was established by history, signs and symptoms, peripheral eosinophilia, chest x-rays and response to combined cessation of treatment and a short course of steroids. Physicians should be aware to this rare adverse effect of the drug. Attention to the possibility of minocycline-induced eosinophilic pneumonia can prevent unnecessary, expensive investigation. Cessation of intake is usually sufficient for cure.
嗜酸性粒细胞性肺炎是米诺环素罕见的不良反应。迄今为止,约有70种化合物可导致药物性嗜酸性粒细胞性肺病。本文描述了一名因米诺环素引发嗜酸性粒细胞性肺炎的20岁女性。通过病史、体征和症状、外周血嗜酸性粒细胞增多、胸部X光检查以及停药联合短期使用类固醇激素后的反应来确诊。医生应注意该药物的这种罕见不良反应。关注米诺环素诱发嗜酸性粒细胞性肺炎的可能性可避免不必要的昂贵检查。通常停药即可治愈。