Shimizu Takashi, Shimizu Natsue, Kinebuchi Shin-ichi, Toyama Jozi
Department of Internal Medicine, Joetsu General Hospital.
Nihon Kokyuki Gakkai Zasshi. 2008 Feb;46(2):136-40.
We reported a case of acute eosinophilic pneumonia (AEP) induced by minocycline. A 55-year-old man presented with a low grade fever and cough and was treated with antibiotics, including minocycline (MINO). During treatment, the patient developed symptoms of acute respiratory failure, and computed tomography (CT) scan showed bilateral ground grass opacities. Bronchoalveolar lavage (BAL) was performed. The percentage of eosinophils in the BAL fluid was elevated (66%). The patient was treated with methylprednisolone under a diagnosis of AEP. Immediately after initiation of therapy, the CT film findings and clinical symptoms improved. Although a drug-induced lymphocyte stimulation test for MINO was negative, we speculated that AEP was caused by MINO in this case.
我们报告了一例由米诺环素引起的急性嗜酸性粒细胞性肺炎（AEP）。一名55岁男性出现低热和咳嗽，接受了包括米诺环素（MINO）在内的抗生素治疗。治疗期间，患者出现急性呼吸衰竭症状，计算机断层扫描（CT）显示双侧磨玻璃样混浊。进行了支气管肺泡灌洗（BAL）。BAL液中嗜酸性粒细胞百分比升高（66%）。该患者在诊断为AEP后接受了甲泼尼龙治疗。治疗开始后，CT影像结果和临床症状立即得到改善。尽管针对米诺环素的药物诱导淋巴细胞刺激试验为阴性，但我们推测本例中的AEP是由米诺环素引起的。
