Boekema P J, Samsom M, Roelofs J M, Smout A J
Department of Gastroenterology, University Medical Center Utrecht, The Netherlands.
Dig Dis Sci. 2001 May;46(5):945-51. doi: 10.1023/a:1010733222245.
Some people attribute dyspeptic symptoms to drinking coffee, suggesting that coffee affects one or more functions of the proximal gastrointestinal tract. In a randomized controlled, cross-over, single-blinded study, the effects of coffee on gastric relaxation, gastric wall compliance and sensations, elicited by distension, were investigated in 10 healthy volunteers. Using the barostat technique, volume changes of an intragastric bag were recorded for 20 min after intragastric administration of 280 ml of coffee or water. Then, after deflation, the volume of the bag was increased stepwise every 3 min to assess gastric wall compliance and wall tension. At the end of every volume step, sensations (nausea, pain, and bloating) were scored. During the first 20 min after coffee administration, the volume change of the intragastric bag was larger than after water (P < 0.05). There were no differences in gastric wall compliance, wall tension, or symptom scores. In conclusions, coffee, in comparison with water, enhances the adaptive relaxation of the proximal stomach, but has no effect on its wall compliance, wall tension, or sensory function.
有些人将消化不良症状归因于喝咖啡，认为咖啡会影响近端胃肠道的一种或多种功能。在一项随机对照、交叉、单盲研究中，对10名健康志愿者研究了咖啡对胃舒张、胃壁顺应性以及由扩张引起的感觉的影响。使用恒压器技术，在胃内给予280毫升咖啡或水后，记录胃内袋的体积变化20分钟。然后，在放气后，每隔3分钟逐步增加袋的体积，以评估胃壁顺应性和壁张力。在每个体积步骤结束时，对感觉（恶心、疼痛和腹胀）进行评分。在给予咖啡后的前20分钟内，胃内袋的体积变化大于给予水后（P<0.05）。胃壁顺应性、壁张力或症状评分没有差异。总之，与水相比，咖啡可增强近端胃的适应性舒张，但对其胃壁顺应性、壁张力或感觉功能没有影响。
