中枢性尿崩症患儿的低钠血症和多尿：诊断与管理中的挑战

Hyponatremia and polyuria in children with central diabetes insipidus: challenges in diagnosis and management.

作者信息

Ferry R J, Kesavulu V, Kelly A, Levitt Katz L E, Moshang T

机构信息

Divisions of Endocrinology & Diabetes and Critical Care Medicine, Department of Pediatrics, Mattel Children's Hospital at The University of California, Los Angeles, USA.

出版信息

J Pediatr. 2001 May;138(5):744-7. doi: 10.1067/mpd.2001.112651.

DOI:10.1067/mpd.2001.112651

PMID:11343054

Abstract

Five patients with well-controlled, long-standing, central diabetes insipidus had acute development of dehydration, hyponatremia, and inappropriate natriuresis in the setting of polyuria resistant to exogenous antidiuretic hormone. Hyponatremia and dehydration worsened with fluid restriction or use of exogenous antidiuretic hormone. We discuss the challenges in diagnosis and management of probable salt wasting in children with central diabetes insipidus.

摘要

五例长期中枢性尿崩症病情控制良好的患者，在对外源性抗利尿激素抵抗的多尿情况下，急性出现脱水、低钠血症和不适当利钠。限液或使用外源性抗利尿激素会使低钠血症和脱水加重。我们讨论了中枢性尿崩症患儿可能存在的盐耗损在诊断和管理方面的挑战。