Edate Sujata, Albanese Assunta
Paediatric Endocrinology Unit, St. George's Hospital, London, UK.
Horm Res Paediatr. 2015;83(5):293-301. doi: 10.1159/000370065. Epub 2015 Feb 11.
Disturbances in salt and water balances are relatively common in children after brain surgeries for suprasellar and pituitary tumours, presenting diagnostic and therapeutic challenges. Although hypernatraemia associated with central diabetes insipidus is commonly encountered, it is hyponatraemia (HN) that poses more of a diagnostic dilemma. The main differential diagnoses causing HN are the syndrome of inappropriate antidiuretic hormone secretion, marked by inappropriate retention of water, and cerebral salt wasting, characterized by polyuria and natriuresis. Diagnosis and management can be even more difficult when these conditions precede or coexist with each other. These diagnostic and therapeutic dilemmas are discussed in detail in this review.
在接受鞍上和垂体肿瘤脑手术的儿童中,盐和水平衡紊乱相对常见,这带来了诊断和治疗方面的挑战。虽然与中枢性尿崩症相关的高钠血症很常见,但低钠血症(HN)才是更具诊断难题的情况。导致HN的主要鉴别诊断是抗利尿激素分泌不当综合征,其特征是水潴留不当,以及脑性盐耗综合征,其特征是多尿和尿钠排泄。当这些情况相互先后出现或同时存在时,诊断和管理会更加困难。本综述将详细讨论这些诊断和治疗难题。